Description

Boc-D-Methionine Sulfoxide is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. Its primary value lies in its role as a key chiral building block for introducing the D-methionine sulfoxide moiety into complex molecules, enabling the study of protein oxidation and the development of novel therapeutic peptides. This compound is critically needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on peptide-based drug discovery and biochemical studies.

Application

• Peptide Synthesis: As a crucial chiral intermediate for the solid-phase and solution-phase synthesis of complex peptides containing oxidized methionine residues.
• Pharmaceutical Research: For the development and study of peptide-based drug candidates, particularly those targeting diseases related to protein oxidation and aging.
• Biochemical Studies: Used as a standard or reagent in research investigating the role of methionine sulfoxide in protein function, signaling, and redox regulation.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group allows for orthogonal protection strategies in multi-step organic syntheses.
• Asymmetric Synthesis: Serves as a chiral pool starting material or auxiliary for the construction of non-proteinogenic amino acids and other bioactive molecules.
• Reference Standard: For analytical method development and quality control in pharmaceutical manufacturing of peptide APIs.

Basic Information

Product Name	Boc-D-Methionine Sulfoxide
CAS No.	81444-65-7
Molecular Formula	C10H19NO5S
Molecular Weight	265.33 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-4-(methylsulfinyl)butanoic acid; N-(tert-Butoxycarbonyl)-D-methionine sulfoxide; Boc-D-Met(O); Boc-D-Met(O)-OH; N-Boc-D-methionine S-oxide; D-Methionine sulfoxide, N-Boc derivative; tert-Butyl (R)-2-amino-4-(methylsulfinyl)butanoate carboxylic acid; BOC-D-METHIONINE S-OXIDE
EINECS	Contact for details

Quality Control

Our Boc-D-Methionine Sulfoxide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, assay, and impurity profiles. Our quality commitment aligns with the standards expected for fine chemical and non-compendial building blocks used in advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.