Description

Thiophene, 2-Ethynyl-5-Methyl- is a specialized heterocyclic building block featuring a reactive ethynyl group on the thiophene core. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling and click chemistry reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides with enhanced efficacy.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for transition metal catalysis and organometallic complexes.
• Click Chemistry Substrate: The terminal alkyne group makes it an ideal participant in Huisgen cycloaddition (click) reactions for bioconjugation and polymer functionalization.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	Thiophene, 2-Ethynyl-5-Methyl-
CAS No.	81294-10-2
Molecular Formula	C7H6S
Molecular Weight	122.19 g/mol
Synonyms	2-Ethynyl-5-methylthiophene; 5-Methyl-2-ethynylthiophene; 2-Ethynyl-5-methyl-thiophene; 5-Methylthiophene-2-acetylene; 2-Methyl-5-ethynylthiophene (incorrect but common); Methyl ethynyl thiophene; Thiophene acetylene derivative
EINECS	Contact for details

Quality Control

Our Thiophene, 2-Ethynyl-5-Methyl- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.