Description

1-Piperazineethanol, 4-(2-Chloro-10,11-Dihydro-6-Methoxydibenzo(B,F)Thiepin-10-Yl)-, Dimethanesulfonate (Salt) is a high-purity pharmaceutical intermediate and active ingredient salt form, critical for ensuring the stability and efficacy of final drug formulations. This compound is valued for its role in the synthesis of advanced therapeutic agents, particularly in the central nervous system (CNS) and neuropharmacology sectors. It is essential for manufacturers in the pharmaceutical and biotechnology industries requiring reliable, high-quality building blocks for research and production.

Application

• Key Intermediate in Antipsychotic Drug Synthesis: Primarily used in the manufacturing of dibenzothiepin-based neuroleptic and antipsychotic medications.
• Pharmaceutical Active Pharmaceutical Ingredient (API): Serves as the salt form of an API for improved solubility and stability in final dosage forms.
• Neurological & Psychiatric Research: A crucial compound in preclinical and clinical research targeting CNS disorders.
• Process Development & Scale-Up: Used by process chemists for optimizing synthetic routes and scaling production from lab to commercial batch.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.
• Custom Synthesis & Contract Manufacturing: A building block for specialized contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Item	Details
Product Name	1-Piperazineethanol, 4-(2-Chloro-10,11-Dihydro-6-Methoxydibenzo(B,F)Thiepin-10-Yl)-, Dimethanesulfonate (Salt)
CAS No.	81223-37-2
Molecular Formula	C23H29ClN2O6S3
Molecular Weight	569.13 g/mol
Synonyms	Zotepine Dimethanesulfonate; Zotepine Mesylate; 10-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-chloro-6-methoxy-10,11-dihydrodibenzo[b,f]thiepin dimethanesulfonate; 2-Chloro-10-[4-(2-hydroxyethyl)-1-piperazinyl]-6-methoxydibenzo[b,f]thiepin dimethanesulfonate; FR-1314 Dimethanesulfonate; Lodopin Impurity (Mesylate Salt); Nipolept Dimethanesulfonate
EINECS	Contact for details

Quality Control

Our 1-Piperazineethanol, 4-(2-Chloro-10,11-Dihydro-6-Methoxydibenzo(B,F)Thiepin-10-Yl)-, Dimethanesulfonate (Salt) is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring reliability for GMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.