Description

Leucine, 3-Hydroxy-, Methyl Ester (9Ci) is a specialized amino acid derivative, specifically the methyl ester of 3-hydroxy-L-leucine. This compound is valued as a crucial chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex bioactive molecules, peptides, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting metabolic and neurological pathways.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to incorporate modified leucine residues, influencing peptide stability and bioactivity.
• Biochemical Research: Serves as a precursor or standard in metabolic studies and enzymatic research related to branched-chain amino acid metabolism.
• Agrochemical Development: Employed as an intermediate in creating novel herbicides, fungicides, or plant growth regulators with specific stereochemical requirements.
• Fine Chemical Synthesis: Acts as a versatile building block for synthesizing complex natural products, flavors, fragrances, and specialty chemicals.
• Proteomics & Labeling Reagents: Potential use in the development of isotopic labeling agents or chemical probes for mass spectrometry-based proteomic analysis.

Basic Information

Product Name	Leucine, 3-Hydroxy-, Methyl Ester (9Ci)
CAS No.	81202-41-7
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	3-Hydroxy-L-leucine methyl ester; Methyl 3-hydroxy-L-leucinate; (2S)-2-Amino-4-methyl-3-hydroxy-pentanoic acid methyl ester; L-Leucine, 3-hydroxy-, methyl ester; Methyl (2S)-2-amino-3-hydroxy-4-methylpentanoate
EINECS	Contact for details

Quality Control

Our Leucine, 3-Hydroxy-, Methyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets high-purity standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.