Description

Cbz-n-Methyl-Dl-Phenylalanine CAS NO 81134-79-4 is a protected amino acid derivative, specifically an N-methylated phenylalanine with a carboxybenzyl (Cbz) protecting group on the amine. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics and drug candidates.
• Peptide Synthesis: Serves as a protected N-methyl amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to modulate the biological activity, metabolic stability, and conformational properties of peptide leads.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex molecules in pilot plants and manufacturing.
• Biochemical Research: Utilized in the study of enzyme-substrate interactions and the development of enzyme inhibitors.
• Academic Research: A valuable reagent for universities and research institutes exploring synthetic methodologies and new chemical entities.

Basic Information

Product Name	Cbz-n-Methyl-Dl-Phenylalanine
CAS No.	81134-79-4
Molecular Formula	C18H19NO4
Molecular Weight	313.35 g/mol
Synonyms	N-Carbobenzyloxy-N-methyl-DL-phenylalanine; N-(Benzyloxycarbonyl)-N-methyl-DL-phenylalanine; Z-N-Me-DL-Phe-OH; (RS)-2-[(Benzyloxycarbonyl)(methyl)amino]-3-phenylpropanoic acid; N-Cbz-N-methyl-DL-phenylalanine; DL-N-Methyl-N-carbobenzoxyphenylalanine; N-Methyl-N-(benzyloxycarbonyl)-DL-phenylalanine; Benzyl N-methyl-N-[(RS)-1-carboxy-2-phenylethyl]carbamate
EINECS	Contact for details

Quality Control

Our Cbz-n-Methyl-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-Racemate
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.