Description

Neurotensin (1-8) is a bioactive octapeptide fragment derived from the endogenous neuropeptide Neurotensin. This specific sequence retains significant biological activity, making it a valuable tool for neuroscience and pharmacological research. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for studying receptor interactions, signal transduction pathways, and developing novel therapeutic agents.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of the central nervous system, including investigations into dopamine modulation, pain perception, and thermoregulation.
• Pharmacological Studies: Employed in in vitro and in vivo assays to characterize Neurotensin receptor (NTS1 and NTS2) binding, activation, and downstream effects.
• Biochemical Reagent: Serves as a critical reagent in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other analytical methods for quantifying neurotensin-related peptides.
• Drug Discovery & Development: Acts as a lead compound or molecular scaffold for the design and synthesis of novel neurotensin analogs with potential therapeutic applications in schizophrenia, addiction, and cancer.
• Cell Culture & Physiology: Applied in cell-based experiments to study cellular responses, receptor internalization, and the role of neurotensin in gastrointestinal and cardiovascular functions.

Basic Information

Item	Details
Product Name	Neurotensin (1-8)
CAS No.	80887-44-1
Molecular Formula	C₄₅H₆₉N₁₃O₁₂
Molecular Weight	1000.1 g/mol
Synonyms	L-Pyroglutamyl-L-leucyl-L-tyrosyl-L-glutamyl-L-asparaginyl-L-lysyl-L-prolyl-L-arginine; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg; NT (1-8); Neurotensin 1-8; Neurotensin fragment 1-8; H-pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-OH
EINECS	Contact for details

Quality Control

Every batch of Neurotensin (1-8) is manufactured and analyzed under strict quality management protocols to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Our products undergo rigorous quality testing, including multiple orthogonal analytical methods. Certificates of Analysis (COA) providing detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.