Description

2-Methoxy-2-Phenyl-3,3,3-Trifluoropropionitrile is a specialized fluorinated organic intermediate of significant interest in advanced chemical synthesis. This compound is valued for its unique trifluoromethyl and cyano functional groups, which are key motifs in the development of molecules with tailored properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex, high-value target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl group to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for novel fluorinated polymers, liquid crystals, or organic electronic materials due to its unique electronic properties.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex molecular architectures via reactions involving the cyano and methoxy-phenyl groups.
• Fluorine Chemistry Studies: Acts as a model compound for investigating new fluorination methodologies and the behavior of fluorinated nitriles in various reaction conditions.

Basic Information

Product Name	2-Methoxy-2-Phenyl-3,3,3-Trifluoropropionitrile
CAS No.	80866-87-1
Molecular Formula	C11H10F3NO
Molecular Weight	229.20 g/mol
Synonyms	α-Methoxy-α-phenyl-β,β,β-trifluoropropionitrile; 2-Methoxy-2-phenyl-3,3,3-trifluoropropanenitrile; 2-Phenyl-2-methoxy-3,3,3-trifluoropropionitrile; 3,3,3-Trifluoro-2-methoxy-2-phenylpropionitrile; Trifluoromethylated Mandelonitrile Methyl Ether; (Methoxyphenyl)(trifluoromethyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 2-Methoxy-2-Phenyl-3,3,3-Trifluoropropionitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay (by HPLC or GC), impurity profile, and physical characteristics. Our quality commitment supports applications requiring high-purity intermediates for research and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.