Description

Benzeneacetic Acid, 4-(Difluoromethoxy)-α,α-Dimethyl- is a specialized fluorinated organic compound that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring a difluoromethoxy substituent, makes it a valuable intermediate for creating molecules with enhanced metabolic stability and bioavailability. This high-purity intermediate is primarily sought by research and development teams and process chemists in the pharmaceutical and agrochemical industries. It is essential for the synthesis of novel active ingredients where fluorine incorporation is a key design strategy.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Advanced Material Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials that require specific fluorine-based properties.
• Chemical Research & Development: Serves as a versatile fluorinated building block in academic and industrial R&D labs for exploring new chemical spaces and reaction pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	Benzeneacetic Acid, 4-(Difluoromethoxy)-α,α-Dimethyl-
CAS No.	80854-27-9
Molecular Formula	C11H12F2O3
Molecular Weight	230.21 g/mol
Synonyms	4-(Difluoromethoxy)-α,α-dimethylbenzeneacetic acid; 2-[4-(Difluoromethoxy)phenyl]-2-methylpropanoic acid; α,α-Dimethyl-4-(difluoromethoxy)benzeneacetic acid; p-(Difluoromethoxy)-α,α-dimethylphenylacetic acid; Difluoromethoxy-α-methylhydrocinnamic acid (derivative); 80854-27-9; Benzeneacetic acid, 4-(difluoromethoxy)-α,α-dimethyl-
EINECS	Contact for details

Quality Control

Our Benzeneacetic Acid, 4-(Difluoromethoxy)-α,α-Dimethyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and specific impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.