Description

Des(Ala-Lys)-Calmodulin CAS NO 80801-19-0 is a specifically modified fragment of the ubiquitous calcium-binding messenger protein, calmodulin. This engineered peptide is a critical research tool for studying calcium signal transduction pathways and protein-protein interactions without the interference of the native Ala-Lys sequence. It is primarily utilized by researchers and developers in biochemical research, pharmaceutical discovery, and diagnostic assay development who require high-purity, well-characterized protein fragments for mechanistic studies and screening applications.

Application

• Biochemical Research: Used as a substrate or binding partner in studies of calcium/calmodulin-dependent enzyme regulation, such as kinases and phosphatases.
• Drug Discovery Screening: Serves as a target in high-throughput assays to identify novel modulators of calmodulin-mediated signaling pathways.
• Structural Biology: Employed in X-ray crystallography and NMR studies to elucidate the structural determinants of calmodulin-target protein interactions.
• Diagnostic Development: Can be used in the development of immunoassays or biosensors for detecting calmodulin or its binding partners.
• Enzyme Activity Studies: Acts as a specific activator or inhibitor in functional assays for enzymes like nitric oxide synthase or calcineurin.
• Educational & Reference Standard: Provides a defined, modified calmodulin standard for academic teaching and quality control in related research kits.

Basic Information

Product Name	Des(Ala-Lys)-Calmodulin
CAS No.	80801-19-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Calmodulin (1-148, des-Ala-Lys); Calmodulin fragment 1-148; Des-Ala-Lys-Calmodulin; CaM (δAla-Lys); Recombinant Des(Ala-Lys)-Calmodulin; Calcium-modulated protein fragment; CaM mutant (Ala-Lys deletion); CAM_HUMAN (1-148, des-Ala-Lys)
EINECS	Contact for details

Quality Control

Our Des(Ala-Lys)-Calmodulin is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and functional activity assays. Certificates of Analysis (COA) detailing purity, concentration, and specific test results are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Biological Activity	Contact for details
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.