Description

1-Piperazineethanol, 4-(10,11-Dihydro-3-Fluoro-8-Iododibenzo(B,F)Thiep In-10-Yl)-, (Z)-2-Butenedioate (1:2) is a high-purity, non-racemic pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the central nervous system (CNS) domain. It is primarily utilized by pharmaceutical R&D laboratories and advanced chemical synthesis facilities requiring precise stereochemistry and reliable batch-to-batch consistency for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel psychotropic and neuroactive drug candidates.
• Chemical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in API manufacturing.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of target active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying receptor binding and neurochemical pathways.

Basic Information

Product Name	1-Piperazineethanol, 4-(10,11-Dihydro-3-Fluoro-8-Iododibenzo(B,F)Thiep In-10-Yl)-, (Z)-2-Butenedioate (1:2)
CAS No.	80760-86-7
Molecular Formula	C21H22FIN2OS • 1.5C4H4O4
Molecular Weight	Contact for details
Synonyms	Zuclopenthixol Acetate Impurity; (Z)-2-Butenedioic acid, compd. with 4-[10,11-dihydro-3-fluoro-8-iododibenzo[b,f]thiepin-10-yl]-1-piperazineethanol (2:1); 4-[10,11-Dihydro-3-fluoro-8-iododibenzo[b,f]thiepin-10-yl]-1-piperazineethanol hemifumarate; Zuclopenthixol Acetate Related Compound; Zuclopenthixol impurity; 1-Piperazineethanol, 4-(10,11-dihydro-3-fluoro-8-iododibenzo[b,f]thiepin-10-yl)-, (2Z)-2-butenedioate (2:1)
EINECS	Contact for details

Quality Control

Our 1-Piperazineethanol, 4-(10,11-Dihydro-3-Fluoro-8-Iododibenzo(B,F)Thiep In-10-Yl)-, (Z)-2-Butenedioate (1:2) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and chiral purity, residual solvent analysis, and identification by spectroscopic methods to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.