Description

H-Arg(Mtr)-Oh CAS NO 80745-10-4 is a protected arginine derivative, specifically featuring the 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) protecting group on the guanidino side chain. This compound is a critical building block in the solid-phase peptide synthesis (SPPS) of complex peptides and proteins, enabling the precise construction of sequences containing arginine. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity intermediates for developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid monomer for the automated synthesis of peptide chains.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic and research applications.
• Biochemical Tool Development: Employed in the synthesis of substrates, inhibitors, and probes for enzyme studies and assay development.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental studies in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	H-Arg(Mtr)-Oh
CAS No.	80745-10-4
Molecular Formula	C17H26N4O6S
Molecular Weight	414.48 g/mol
Synonyms	NG-(4-Methoxy-2,3,6-trimethylbenzenesulfonyl)-L-arginine; L-Arginine, N2-[N-[4-methoxy-2,3,6-trimethylphenyl)sulfonyl]carbamimidoyl]-; Arg(Mtr)-OH; Fmoc-Arg(Mtr)-OH (precursor form); Mtr-L-Arg-OH; Nω-Mtr-L-arginine; 4-Methoxy-2,3,6-trimethylbenzenesulfonyl arginine; Protected L-arginine derivative
EINECS	Contact for details

Quality Control

Our H-Arg(Mtr)-Oh is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation. We provide full traceability and a Certificate of Analysis (COA) with each shipment, ensuring compliance with the stringent requirements of pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.