Description

Neridronate Sodium Salt CAS NO 80729-79-9 is a high-purity bisphosphonate compound, a sodium salt form of neridronic acid, designed for pharmaceutical research and development. This compound is valued for its potent inhibitory activity against osteoclast-mediated bone resorption, making it a critical intermediate in the development of treatments for bone metabolism disorders. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on osteoporosis, Paget's disease, and other conditions involving abnormal calcium metabolism.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Serves as the key active component in the formulation of injectable or oral bisphosphonate drugs.
• Osteoporosis Treatment R&D: Used in preclinical and clinical research for developing therapies to increase bone mineral density and reduce fracture risk.
• Paget's Disease of Bone: Investigated for its efficacy in normalizing bone turnover in this chronic skeletal disorder.
• Heterotopic Ossification Prevention: Studied for application in preventing abnormal bone formation following total hip replacement or spinal cord injury.
• Oncology Supportive Care: Research into mitigating bone metastases and managing hypercalcemia of malignancy.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Used to study the mevalonate pathway and farnesyl pyrophosphate synthase (FPPS) inhibition mechanisms.

Basic Information

Item	Details
Product Name	Neridronate Sodium Salt
CAS No.	80729-79-9
Molecular Formula	C7H16NNaO7P2
Molecular Weight	311.14 g/mol
Synonyms	Neridronate Disodium; Neridronic Acid Disodium Salt; (6-Amino-1-hydroxy-1-phosphonohexyl)phosphonic Acid Disodium Salt; Aminohexane-1,1-bisphosphonic Acid Disodium Salt; AHBP Disodium; Nerixia; Sodium Neridronate; Neridronato Disodico
EINECS	Contact for details

Quality Control

Our Neridronate Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting results for identity, purity, residual solvents, and heavy metals are provided with every shipment. Production adheres to cGMP guidelines where applicable, supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. The container should be kept tightly sealed in a desiccated environment after each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
pH (1% Solution)	6.0 - 8.0
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.