Description

1-(10,11-Dihydro-7,8-Dimethoxydibenzo(B,F)Thiepin-10-Yl)-4-Methylpiperazine Maleate Hydrate is a high-purity, complex organic compound primarily utilized as a critical pharmaceutical intermediate. Its value lies in enabling the synthesis of advanced active pharmaceutical ingredients (APIs) with precise structural and stereochemical requirements. This compound is essential for research and development laboratories, custom synthesis houses, and pharmaceutical manufacturers focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel psychotropic or neurological drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Process Chemistry: Used in scaling up synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	1-(10,11-Dihydro-7,8-Dimethoxydibenzo(B,F)Thiepin-10-Yl)-4-Methylpiperazine Maleate Hydrate
CAS No.	80709-64-4
Molecular Formula	C26H32N2O6S • xH2O
Molecular Weight	500.61 g/mol (anhydrous basis)
Synonyms	10-[4-Methyl-1-piperazinyl]-10,11-dihydro-7,8-dimethoxydibenzo[b,f]thiepin maleate hydrate; 1-(10,11-Dihydro-7,8-dimethoxydibenzo[b,f]thiepin-10-yl)-4-methylpiperazine maleate hydrate; Zotepine Impurity; Zotepine Related Compound; Dibenzo[b,f]thiepin derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-(10,11-Dihydro-7,8-Dimethoxydibenzo(B,F)Thiepin-10-Yl)-4-Methylpiperazine Maleate Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, Karl Fischer titration for water content, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed-upon standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a dry environment and opened under conditions of low humidity to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0% w/w
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.