Description

Leu-Enkephalin (Sulfated) is a modified neuropeptide, specifically the sulfated derivative of the endogenous opioid pentapeptide Leu-Enkephalin. This sulfation significantly alters its receptor binding profile and metabolic stability, making it a critical tool for studying opioid receptor subtypes and neuropeptide signaling pathways. It is essential for researchers and developers in neuroscience, pharmacology, and drug discovery, particularly for investigating pain mechanisms, addiction, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and autoradiography to study delta (δ) and mu (μ) opioid receptor distribution and function.
• Pharmacological Studies: A key reference standard for investigating the structure-activity relationships (SAR) of sulfated neuropeptides and their physiological effects.
• Biochemical Assay Development: Serves as a critical component in the development and validation of high-throughput screening (HTS) assays for opioid receptor activity.
• Drug Discovery & Development: Utilized as a molecular tool for target validation and the preclinical evaluation of new analgesic or neuropsychiatric drug candidates.
• Academic & Institutional Research: Fundamental for basic research into endogenous opioid systems, peptide metabolism, and signal transduction mechanisms.
• Biopharmaceutical Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in peptide-based pharmaceutical production.

Basic Information

Product Name	Leu-Enkephalin (Sulfated)
CAS No.	80632-52-6
Molecular Formula	C28H37N5O10S
Molecular Weight	635.69 g/mol
Synonyms	Tyr-Gly-Gly-Phe-Leu-Sulfate; [Leu5]-Enkephalin Sulfate; H-Tyr-Gly-Gly-Phe-Leu-OH (sulfated); Leu-Enkephalin sulfate ester; L-Leu-Enkephalin Sulfate; Opioid peptide LY 164929 sulfate; YGGFL-Sulfate
EINECS	Contact for details

Quality Control

Our Leu-Enkephalin (Sulfated) is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, MS, and NMR, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.