Description

(R)-1-(3-Bromo-2-Methyl-1-Oxopropyl)-L-Proline is a high-purity chiral building block and proline derivative of significant interest in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other biologically active molecules.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in asymmetric catalytic reactions and stereoselective transformations.
• Peptidomimetics Research: Used in the design and synthesis of peptidomimetic compounds to modulate protein-protein interactions.
• Agrochemical Synthesis: Intermediate in the development of advanced, chiral active ingredients for crop protection.
• Ligand and Catalyst Development: Building block for creating novel chiral ligands and organocatalysts.
• Academic and R&D Laboratories: Used in methodological studies and the exploration of new synthetic pathways in organic chemistry.

Basic Information

Product Name	(R)-1-(3-Bromo-2-Methyl-1-Oxopropyl)-L-Proline
CAS No.	80629-36-3
Molecular Formula	C9H14BrNO3
Molecular Weight	264.12 g/mol
Synonyms	(R)-1-(3-Bromo-2-methylpropanoyl)-L-proline; L-Proline, 1-[(1R)-3-bromo-2-methyl-1-oxopropyl]-; (R)-1-(3-Bromo-2-methylpropionyl)-L-proline; (2R)-1-(3-Bromo-2-methylpropanoyl)pyrrolidine-2-carboxylic acid; Boc-L-Proline derivative (brominated); 3-Bromo-2-methylpropionyl-L-proline (R-isomer); 80629-36-3 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our (R)-1-(3-Bromo-2-Methyl-1-Oxopropyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.