Description

1-[(2S)-3-Bromo-2-Methyl-1-Oxopropyl]-L-Proline is a high-purity, chiral proline derivative characterized by its bromomethyl ketone functional group. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in asymmetric synthesis. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of protease inhibitors and other active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block for constructing complex, enantiomerically pure molecules in medicinal chemistry.
• Peptidomimetic Research: Serves as a proline-based scaffold for designing and synthesizing peptide analogs and enzyme inhibitors.
• Chemical Biology Probes: Used in the development of activity-based probes (ABPs) targeting specific enzymes due to its electrophilic warhead.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Academic Research: A valuable reagent for university and institutional research in organic methodology and drug discovery.

Basic Information

Product Name	1-[(2S)-3-Bromo-2-Methyl-1-Oxopropyl]-L-Proline
CAS No.	80629-35-2
Molecular Formula	C9H14BrNO3
Molecular Weight	264.12 g/mol
Synonyms	(2S)-1-[(2S)-3-Bromo-2-methylpropanoyl]pyrrolidine-2-carboxylic acid; L-Proline, 1-[(2S)-3-bromo-2-methyl-1-oxopropyl]-; 3-Bromo-2-methyl-1-oxopropyl-L-proline; N-[(2S)-3-Bromo-2-methylpropionyl]-L-proline; (S)-1-(3-Bromo-2-methylpropanoyl)pyrrolidine-2-carboxylic acid; Boc-protected precursor derivatives
EINECS	Contact for details

Quality Control

Our 1-[(2S)-3-Bromo-2-Methyl-1-Oxopropyl]-L-Proline is manufactured under cGMP-compliant conditions where applicable, ensuring traceability and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to meet stringent customer specifications. Comprehensive Certificates of Analysis (COA) detailing identity, assay, impurity profile, and physical characteristics are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.