Description

Technetium Tc 99M 3-Amino-1-Hydroxypropane-1,1-Diphosphonate is a radiopharmaceutical complex used as a diagnostic imaging agent in nuclear medicine. This compound is critical for its ability to target and visualize bone metabolism, providing essential diagnostic information for various skeletal conditions. It is primarily required by hospitals, diagnostic imaging centers, and radiopharmacies for performing bone scintigraphy scans.

Application

• Bone Scintigraphy (Bone Scan): Primary diagnostic tool for detecting bone metastases, fractures, infections (osteomyelitis), and assessing prosthetic joint complications.
• Oncology Imaging: Evaluation of the extent (staging) of cancers known to metastasize to bone, such as breast, prostate, and lung cancer.
• Orthopedic Assessment: Diagnosis of stress fractures, shin splints, and other sports injuries not visible on standard X-rays.
• Metabolic Bone Disease Evaluation: Assessment of conditions like Paget's disease of bone and complex regional pain syndrome.
• Infection Imaging: Localization of bone and joint infections.
• Pre-Surgical Planning: Mapping of bone activity prior to orthopedic surgeries.

Basic Information

Product Name	Technetium Tc 99M 3-Amino-1-Hydroxypropane-1,1-Diphosphonate
CAS No.	80549-01-5
Molecular Formula	C3H11NO7P2 • 99mTc
Molecular Weight	Contact for details
Synonyms	Technetium-99m AHDP; Tc-99m AHDP; 99mTc-AHDP; 3-Amino-1-hydroxypropylidene-1,1-bisphosphonate Technetium-99m; Technetium Tc 99m Oxidronate; 99mTc-Oxidronate; [99mTc]Tc-AHDP; Bone Scan Agent (AHDP-based)
EINECS	Contact for details

Quality Control

Every batch of Technetium Tc 99M 3-Amino-1-Hydroxypropane-1,1-Diphosphonate is manufactured and tested under strict radiopharmaceutical GMP (Good Manufacturing Practice) guidelines. Quality assurance includes rigorous testing for radiochemical purity, radionuclidic purity, pH, sterility, and apyrogenicity to ensure patient safety and imaging efficacy. A comprehensive Certificate of Analysis (COA) detailing all release specifications is provided with each shipment.

Storage

Preserve in the original, appropriately shielded, and tightly closed container as supplied. Store at controlled room temperature (15-25°C) or as directed on the kit label. This preparation is light-sensitive and must be protected from light. Use within the specified time frame post-reconstitution/radiolabeling as radioactive decay reduces efficacy. Follow all applicable radiation safety protocols.

Specification

Item	Specification
Appearance	Clear, colorless to slightly pale solution
pH	5.0 - 7.0
Radiochemical Purity (HPLC/TLC)	≥ 95%
Radionuclidic Purity (Gamma Spectroscopy)	≥ 99.9% 99mTc
Sterility Test (Membrane Filtration)	Sterile
Bacterial Endotoxins (LAL)	< 175 EU/Vial
Radioactivity Concentration	As per COA at reference time

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.