Description

Trt-Thr-Oh Dea CAS NO 80514-77-8 is a protected amino acid derivative, specifically the tert-butyloxycarbonyl (Boc) and trityl (Trt) protected form of threonine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of peptides containing threonine residues.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Biochemical Reagent Production: Used to synthesize custom peptides for use as antigens, substrates, or standards in laboratory assays.
• Cosmeceutical Peptide Synthesis: A raw material for creating bioactive peptides used in advanced skincare and cosmetic formulations.

Basic Information

Product Name	Trt-Thr-Oh Dea
CAS No.	80514-77-8
Molecular Formula	C27H29NO5
Molecular Weight	447.52 g/mol
Synonyms	Boc-Thr(Trt)-OH; Boc-L-Threonine(Trityl)-OH; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-(trityloxy)butanoic Acid; N-α-Boc-O-trityl-L-threonine; Boc-Thr(Trt)-OH·dicyclohexylamine; Boc-L-Thr(Trt)-OH; tert-Butyloxycarbonyl-threonine(trityl)-OH; Boc-Threonine(Trt)-OH
EINECS	Contact for details

Quality Control

Our Trt-Thr-Oh Dea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	[α]²⁰D = +15.0° to +20.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.