Description

Rac N'-Nitrosonornicotine CAS NO 80508-23-2 is a nitrosamine derivative of nornicotine, a key compound in tobacco alkaloid research. This chemical is of significant interest in analytical and toxicological studies, particularly for the investigation of nitrosamine formation and metabolism. It serves as a critical reference standard and research material for scientists in the fields of analytical chemistry, pharmacology, and regulatory science, enabling precise quantification and method development.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods, including HPLC, GC-MS, and LC-MS/MS.
• Toxicology Research: Essential for studying the carcinogenic potential, metabolic pathways, and biological activity of tobacco-specific nitrosamines (TSNAs).
• Method Development & Validation: Used by testing laboratories to develop, optimize, and validate sensitive detection methods for nitrosamine impurities in various matrices.
• Regulatory Compliance Testing: Supports compliance testing for nitrosamine limits in pharmaceuticals, tobacco products, and other consumer goods as per FDA, EMA, and ICH guidelines.
• Academic & Industrial R&D: Facilitates fundamental research in organic chemistry, chemical carcinogenesis, and the development of mitigation strategies for nitrosamine contamination.
• Quality Control: Employed as an internal standard or spiking agent in quality control laboratories to ensure accuracy and precision in nitrosamine analysis.

Basic Information

Product Name	Rac N'-Nitrosonornicotine
CAS No.	80508-23-2
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	N-Nitrosonornicotine; NNN; rac-N'-Nitrosonornicotine; (±)-N'-Nitrosonornicotine; 1-(3-Pyridinyl)-4-(nitrosoamino)-1-butanone; N'-Nitroso-nornicotine; Tobacco-specific nitrosamine NNN; 4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanone (common mis-association, listed for clarity); TSNA Reference Standard
EINECS	Contact for details

Quality Control

Our Rac N'-Nitrosonornicotine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, related substances, and residual solvents, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C) to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.