Description

Insulin, 4-(Azidophenylacetyl)-2,4-Diaminobutyric Acid(A1)- CAS NO 80498-14-2 is a chemically modified insulin derivative, specifically engineered for advanced biochemical research and pharmaceutical development. This compound is critical for studying insulin signaling pathways, receptor interactions, and for the development of novel diagnostic or therapeutic conjugates. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on endocrinology, diabetes research, and targeted drug delivery systems.

Application

• Biochemical Research: A key tool for investigating the structure-activity relationship (SAR) of insulin and its receptor binding mechanisms.
• Pharmaceutical Development: Serves as a precursor or intermediate in the synthesis of novel insulin analogs or insulin-based conjugates for therapeutic applications.
• Proteomics & Labeling Studies: The azido group enables site-specific bioconjugation via click chemistry (e.g., CuAAC, SPAAC) for labeling, imaging, or affinity purification.
• Diagnostic Reagent Manufacturing: Used in the development of immunoassays, biosensors, and diagnostic kits for measuring insulin levels or related biomarkers.
• Academic Research: Employed in university and institutional labs for fundamental studies in metabolism, peptide hormone action, and signal transduction.
• Drug Delivery System Design: Facilitates the creation of targeted delivery systems where insulin is coupled to carriers or other bioactive molecules.

Basic Information

Product Name	Insulin, 4-(Azidophenylacetyl)-2,4-Diaminobutyric Acid(A1)- CAS NO 80498-14-2
CAS No.	80498-14-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-(Azidophenylacetyl)-DAB(A1)-Insulin; A1-Modified Insulin Azide; Insulin A1-(4-Azidophenylacetyl)-2,4-diaminobutyric acid; Insulin derivative, A1-azidophenylacetyl; Azido-Phe-acetyl-DAB(A1)-Insulin; Insulin, 4-azidophenylacetyl-DAB(A1)-; 80498-14-2; Insulin chemical probe
EINECS	Contact for details

Quality Control

Our Insulin, 4-(Azidophenylacetyl)-2,4-Diaminobutyric Acid(A1) is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC and structural confirmation by mass spectrometry. Certificates of Analysis (COA) detailing all relevant specifications are provided to guarantee the product meets the stringent requirements of pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to maintain stability. For long-term storage, keep under argon or nitrogen. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay (Reported on COA)
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.