Description

Mullerian-Inhibiting Hormone (MIH), also known as Anti-Mullerian Hormone (AMH), is a critical glycoprotein hormone belonging to the transforming growth factor-beta (TGF-β) superfamily. It plays an indispensable role in sexual differentiation and reproductive system development, making it a vital reagent for advanced life science research and biopharmaceutical development. This high-purity compound is essential for researchers and developers in endocrinology, reproductive biology, and oncology, particularly for studying gonadal function, fertility, and certain hormone-responsive cancers.

Application

• Biomedical Research: Fundamental studies on sexual differentiation, gonadal development, and the regulation of folliculogenesis in ovaries.
• Fertility and Reproductive Health Assays: Used as a key standard and component in diagnostic kits to measure AMH levels, a crucial marker for ovarian reserve and fertility potential.
• Oncology Research: Investigation of its role and expression in granulosa cell tumors of the ovary and other hormone-sensitive cancers.
• Drug Discovery & Development: Target validation and screening for therapeutic agents aimed at modulating the AMH pathway for treating reproductive disorders or cancers.
• Cell Culture & In Vitro Studies: Addition to cell culture media to study its effects on specific cell lines, including Sertoli and granulosa cells.
• Antibody Production & Immunoassays: Serves as a high-quality antigen for the generation of specific monoclonal and polyclonal antibodies.

Basic Information

Product Name	Mullerian-Inhibiting Hormone
CAS No.	80497-65-0
Molecular Formula	CₙHₘNₓOₚSₜ (Glycoprotein)
Molecular Weight	Approx. 140-145 kDa (dimer)
Synonyms	Anti-Mullerian Hormone (AMH); AMH Hormone; Mullerian Inhibiting Substance (MIS); MIS/AMH; Anti-Mullerian Factor; Mullerian Duct Inhibiting Hormone; Glycoprotein Hormone Dimer; TGF-β Family Protein
EINECS	Contact for details

Quality Control

Our Mullerian-Inhibiting Hormone is produced and handled under stringent conditions to ensure the highest standards of purity and biological activity. Each batch undergoes comprehensive analytical testing, including HPLC for purity, SDS-PAGE for molecular weight verification, and bioactivity assays. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, endotoxin levels, and specific activity. We adhere to relevant quality management systems to support research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Molecular Weight (SDS-PAGE)	~72 kDa (monomer), ~145 kDa (dimer)
Biological Activity	Determined by specific bioassay
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.