Description

Rac-Erythro-Dihydro Bupropion Hydrochloride CAS NO 80478-43-9 is a key chiral intermediate and metabolite of the antidepressant drug bupropion. This compound matters for its critical role in pharmaceutical research and development, particularly in the study of metabolic pathways, stereochemistry, and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, analytical reference standard suppliers, and manufacturers engaged in the synthesis of complex neuropharmacological agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for method development and validation in pharmacokinetic and bioequivalence studies.
• Metabolite Research: Essential for investigating the metabolic fate, activity, and toxicity profile of bupropion in preclinical and clinical research.
• Chiral Synthesis Intermediate: Serves as a critical building block in the stereoselective synthesis of bupropion analogs and related therapeutic compounds.
• Active Pharmaceutical Ingredient (API) Development: Utilized in the research and process development for new dosage forms or sustained-release formulations.
• Biochemical Research: Applied in studies targeting neurotransmitter reuptake inhibition mechanisms relevant to depression and smoking cessation.
• Quality Control & Testing: Employed by pharmaceutical manufacturers for in-house quality control and impurity profiling of bupropion-based drug products.

Basic Information

Product Name	Rac-Erythro-Dihydro Bupropion Hydrochloride
CAS No.	80478-43-9
Molecular Formula	C13H19ClNO
Molecular Weight	240.75 g/mol
Synonyms	(±)-Erythro-dihydrobupropion hydrochloride; 2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol hydrochloride; BW 306U hydrochloride; Hydrochloride salt of rac-erythro-dihydrobupropion; (1RS,2SR)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-ol hydrochloride; Bupropion metabolite hydrochloride; AHR-11748 hydrochloride
EINECS	Contact for details

Quality Control

Our Rac-Erythro-Dihydro Bupropion Hydrochloride is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, residual solvents, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% erythro diastereomer
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.