Description

Ethyl 5-Thioxo-L-Prolinate is a specialized chiral building block and a derivative of the amino acid L-proline, featuring a thioxo (C=S) functional group. This compound is of significant value in organic synthesis and pharmaceutical research, particularly for constructing complex molecules with defined stereochemistry. It serves as a key intermediate for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries, enabling the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and peptidomimetic programs.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where specific chirality impacts biological activity.
• Peptide Chemistry: Serves as a modified proline residue for the synthesis of constrained peptides and peptidomimetics to study protein-protein interactions.
• Catalyst Ligand Precursor: Acts as a starting material for synthesizing novel chiral ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the multistep synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic & Institutional Research: A valuable tool in chemical biology and organic methodology development for exploring new synthetic pathways.

Basic Information

Product Name	Ethyl 5-Thioxo-L-Prolinate
CAS No.	80442-95-1
Molecular Formula	C7H11NO2S
Molecular Weight	173.23 g/mol
Synonyms	L-Proline, 5-thioxo-, ethyl ester; Ethyl (S)-5-thioxopyrrolidine-2-carboxylate; Ethyl L-5-thioxoproline; Ethyl 5-thioxoproline; 5-Thioxoproline ethyl ester; (S)-Ethyl 5-thioxopyrrolidine-2-carboxylate; 2-Pyrrolidinecarboxylic acid, 5-thioxo-, ethyl ester, (S)-
EINECS	Contact for details

Quality Control

Our Ethyl 5-Thioxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and production applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.