Description

Tetracaine-D6 Hydrochloride is a deuterium-labeled analog of the local anesthetic tetracaine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, where it compensates for matrix effects and instrument variability. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of tetracaine and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust, regulatory-compliant (e.g., FDA, EMA) analytical methods for pharmaceutical analysis.
• Forensic and Toxicology Testing: Supports the accurate identification and quantification of tetracaine in forensic investigations and toxicological screenings.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies in pharmacology and medicinal chemistry where tracing the fate of the parent molecule is required.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability-indicating assays for tetracaine-containing drug products.

Basic Information

Item	Detail
Product Name	Tetracaine-D6 Hydrochloride
CAS No.	80404-52-0
Molecular Formula	C15H18D6N2O2·HCl
Molecular Weight	304.84 g/mol (for free base C15H18D6N2O2)
Synonyms	2-(Dimethylamino)ethyl 4-(butylamino)benzoate-d6 hydrochloride; Amethocaine-d6 hydrochloride; Pantocaine-d6 hydrochloride; Dicaine-d6 hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester-d6 hydrochloride; Deuterated Tetracaine HCl; Tetracaine-d6 HCl; [2H6]-Tetracaine Hydrochloride
EINECS	Contact for details

Quality Control

Our Tetracaine-D6 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment, and impurity profile. We adhere to relevant industry standards for high-purity reference materials to ensure data integrity in your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.