Description

8-Methoxy-D3 Psoralen is a deuterated derivative of the naturally occurring furocoumarin, psoralen, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for advanced analytical and research applications where precise quantification and metabolic tracking are required. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in method development, pharmacokinetic studies, and quality control for related active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical reference standard for the accurate quantification of psoralen and its methoxy derivatives in complex biological matrices.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to trace and elucidate metabolic pathways of psoralen-based therapeutics.
• Analytical Method Development: Enables the development and validation of highly sensitive and specific chromatographic methods (HPLC, UPLC) in quality control laboratories.
• Biomedical Research: Acts as a tool compound in photochemotherapy (PUVA) research to study mechanisms of action without interference from metabolic conversion.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the high-precision measurement capabilities required for definitive methods in clinical and forensic toxicology.

Basic Information

Product Name	8-Methoxy-D3 Psoralen
CAS No.	80386-99-8
Molecular Formula	C12H5D3O4
Molecular Weight	219.21 g/mol
Synonyms	8-Methoxypsoralen-d3; 8-MOP-d3; Methoxsalen-d3; Xanthotoxin-d3; 9-Methoxy-7H-furo[3,2-g]chromen-7-one-d3; 8-Methoxy-[D3]psoralen; Deuterated 8-Methoxypsoralen
EINECS	Contact for details

Quality Control

Every batch of our 8-Methoxy-D3 Psoralen is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and solvent content to ensure it meets the exacting standards for use as an internal standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Isotopic Enrichment	≥ 99.0% (D3)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.