Description

Preprocalcitonin is a polypeptide precursor protein that plays a crucial role in the inflammatory response and is a key biomarker for severe bacterial infections and sepsis. Its primary value lies in its use as a reference standard and critical raw material in the research, development, and manufacturing of advanced in vitro diagnostic (IVD) assays. This high-purity biochemical is essential for pharmaceutical R&D laboratories, diagnostic kit manufacturers, and clinical research organizations focused on improving the accuracy and speed of sepsis diagnosis and patient monitoring.

Application

• IVD Assay Development: Serves as the primary reference standard and calibrator for immunoassays (ELISA, CLIA, FIA) measuring procalcitonin (PCT) levels.
• Biomarker Research: Used in clinical and academic research to study the pathophysiology of sepsis, systemic inflammatory response syndrome (SIRS), and other severe infections.
• Diagnostic Kit Manufacturing: A critical raw material for the production of commercial procalcitonin test kits used in hospitals and clinical laboratories worldwide.
• Quality Control: Employed as a control material to ensure the accuracy, precision, and lot-to-lot consistency of diagnostic testing systems.
• Antibody Production & Characterization: Used to generate and validate monoclonal and polyclonal antibodies specific to procalcitonin and its precursors.
• Therapeutic Target Investigation: Supports research into novel therapeutic strategies aimed at modulating the calcitonin gene-related peptide pathway.

Basic Information

Product Name	Preprocalcitonin
CAS No.	80296-97-5
Molecular Formula	C₁₇₀H₂₆₇N₅₁O₅₀S₂
Molecular Weight	~ 14,900 Da
Synonyms	Calcitonin Precursor; Pre-pro-calcitonin; Procalcitonin Precursor; CALCA Preproprotein; PrePCT; PCT(1-141); CALCA (1-141); Calcitonin Gene-Related Peptide I Precursor
EINECS	Contact for details

Quality Control

Our Preprocalcitonin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and biological activity, meeting the exacting standards required for diagnostic and research applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity (by Mass Spectrometry), and endotoxin levels is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Protein Content)	≥ 90.0%
Water Content (KF)	≤ 5.0%
Endotoxin	< 1.0 EU/μg
Biological Activity	Confirmed by immuno-reactivity

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.