Description

Complement Factor I is a critical serine protease that plays a central regulatory role in the complement cascade, a key component of the innate immune system. Its primary function is to inactivate C3b and C4b, thereby controlling amplification and preventing excessive immune activation and host tissue damage. This makes it an essential reagent for research in immunology, autoimmune diseases, and the development of therapeutic complement inhibitors. Professionals in pharmaceutical R&D, clinical diagnostics, and life science research require high-purity, reliable Factor I for their investigative and development workflows.

Application

• Biomedical Research: Fundamental studies of the alternative and classical complement pathways, their regulation, and associated disease mechanisms.
• Therapeutic Development: Target validation and screening assays for novel drugs aimed at modulating complement activity in conditions like paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and age-related macular degeneration (AMD).
• Diagnostic Reagent Manufacturing: A key component in enzyme immunoassays (EIAs) and other in vitro diagnostic (IVD) kits used to assess complement system functionality and deficiencies.
• Quality Control & Standardization: Serves as a reference standard for the calibration and validation of assays measuring complement factor activity in clinical and research laboratories.
• Cell Culture & Protein Interaction Studies: Used in experiments to understand cell surface regulation of complement and its role in immune cell signaling.

Basic Information

Product Name	Complement Factor I
CAS No.	80295-66-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	C3b/C4b Inactivator; Factor I; Complement Factor I; CFI; C3BINA; C3b Inactivator; C4b Inactivator; KAF (Conglutinogen Activating Factor); IF
EINECS	Contact for details

Quality Control

Our Complement Factor I is produced and tested under stringent quality management systems. Each lot undergoes comprehensive analytical characterization to ensure identity, purity, and functional activity. We provide detailed Certificates of Analysis (COA) with each shipment, which include data on purity (by SDS-PAGE and/or HPLC), specific activity, endotoxin levels, and sterility where applicable. Our commitment is to supply research-grade and diagnostic-grade materials that meet the exacting standards required for reproducible scientific and clinical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a non-frost-free freezer. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE/Western Blot)	Consistent with human Complement Factor I
Purity (SDS-PAGE, reduced)	> 90%
Specific Activity	Contact for details
Endotoxin	< 1.0 EU/μg
Protein Concentration	Provided on COA
Buffer Composition	Provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.