Description

C3, Human CAS NO 80295-41-6 is a high-purity biochemical reagent, specifically the third component of the human complement system. This product is essential for research and development in immunology and molecular biology, providing a critical tool for studying the classical complement pathway and its role in immune response. It is primarily utilized by biotechnology firms, pharmaceutical R&D departments, and academic research institutions focused on autoimmune diseases, inflammatory disorders, and therapeutic antibody development.

Application

• Immunological Research: Fundamental studies of the classical complement cascade and its activation mechanisms.
• Biopharmaceutical Development: Used in functional assays to screen and characterize therapeutic monoclonal antibodies, especially those targeting the complement system.
• Diagnostic Reagent Manufacturing: A key component in the production of in-vitro diagnostic (IVD) kits for assessing complement function and related deficiencies.
• Disease Mechanism Studies: Investigation into the role of complement in autoimmune conditions (e.g., lupus, rheumatoid arthritis) and inflammatory diseases.
• Cell-Based Assays: Functional testing in cytotoxicity assays and other cell culture models to study immune-mediated cell lysis.
• Quality Control: Reference standard for the quality assurance of other complement-related reagents and biologics.

Basic Information

Product Name	C3, Human
CAS No.	80295-41-6
Molecular Formula	Contact for details
Molecular Weight	~185 kDa
Synonyms	Complement C3; Complement Component 3; C3 Complement Protein; Human Complement C3; Third Complement Component; C3 Protein, Human; Complement Factor C3; Hypocomplementemia-related Protein
EINECS	Contact for details

Quality Control

Our C3, Human is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, functional activity, and absence of significant contaminants. We adhere to relevant guidelines for biological materials to support your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Aliquot as recommended to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Immunological)	Complies
Purity (SDS-PAGE)	> 95%
Functional Activity (Hemolytic Assay)	> 90% of reference standard
Endotoxin Level (LAL)	< 1.0 EU/μg
Protein Concentration	Specified on COA
Solubility	Reconstitutes clearly in appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.