Description

C1Q, Human is a purified complement component protein essential for initiating the classical pathway of the complement system. This high-purity biological reagent is critical for research and development in immunology, diagnostics, and therapeutic discovery. It is primarily utilized by biotechnology firms, pharmaceutical R&D departments, and clinical diagnostic laboratories for applications ranging from assay development to the study of autoimmune diseases and immune complex disorders.

Application

• Immunological Research: Fundamental studies of the classical complement pathway activation and regulation.
• Diagnostic Assay Development: A key component in ELISA, immunoturbidimetric, and other immunoassays for detecting immune complexes or complement activity.
• Biopharmaceutical Quality Control: Used in potency assays and characterization tests for therapeutic antibodies and other biologics that activate complement.
• Autoimmune Disease Modeling: Research into conditions like lupus, where C1q plays a significant role in pathogenesis.
• Cell-Based Assays: Investigation of complement-dependent cytotoxicity (CDC) and other immune effector functions.
• Standard Reference Material: Serves as a calibrated standard for quantitative complement testing in clinical and research settings.

Basic Information

Product Name	C1Q, Human
CAS No.	80295-33-6
Molecular Formula	Contact for details
Molecular Weight	~460 kDa (Complex)
Synonyms	Complement C1q Subcomponent; Complement Component 1, q Subcomponent; Human Complement C1q; C1q Protein; C1QC; Complement C1q Chain C; C1q Complement Protein
EINECS	Contact for details

Quality Control

Our C1Q, Human is manufactured under stringent conditions to ensure high biological activity and purity. Each lot undergoes comprehensive analytical testing, including SDS-PAGE, Western Blot, and functional activity assays. A detailed Certificate of Analysis (COA) documenting purity, concentration, endotoxin levels, and functional activity is provided with every shipment to guarantee consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -70°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	> 95%
Identification (Western Blot)	Positive for C1q
Functional Activity (Hemolytic Assay)	Conforms to standard
Endotoxin	< 1.0 EU/μg
Protein Concentration	As per COA (typically 0.5 - 1.0 mg/mL)
Buffer	PBS or other specified buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.