Description

3-Chloro-4-Fluorobenzoyl Cyanide is a versatile and high-value aromatic nitrile building block, essential for advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the benzoyl cyanide moiety serves as a key precursor for heterocyclic systems and the halogen substituents allow for selective further functionalization. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing pyrazole, isoxazole, or other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging the halogenated aromatic ring for bioactivity.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, substituted benzene core.
• Chemical Research & Development: Serves as a versatile synthon for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution, facilitated by the chloro and fluoro groups.
• Dye and Pigment Intermediate: Employed in the fine chemical industry for the production of complex organic dyes and pigments.

Basic Information

Product Name	3-Chloro-4-Fluorobenzoyl Cyanide
CAS No.	80277-45-8
Molecular Formula	C8H3ClFNO
Molecular Weight	183.57 g/mol
Synonyms	3-Chloro-4-fluorobenzoyl cyanide; (3-Chloro-4-fluorophenyl)(oxo)acetonitrile; 2-(3-Chloro-4-fluorophenyl)-2-oxoacetonitrile; 3-Chloro-4-fluoro-α-oxobenzeneacetonitrile; 3-Chloro-4-fluorobenzoyl nitrile; α-Oxo-3-chloro-4-fluorobenzeneacetonitrile; 3-Chloro-4-fluorophenacyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorobenzoyl Cyanide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) for each batch, which confirms identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.