Description

4-(3-Hydroxy-Prop-1-Ynyl)-Benzonitrile is a versatile benzonitrile derivative featuring a terminal alkyne and a hydroxyl group, making it a valuable bifunctional building block for advanced organic synthesis. Its molecular structure is specifically engineered to serve as a key intermediate in the creation of complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for chemists and R&D teams in the life sciences and fine chemical industries seeking to develop new active ingredients or functional materials through cross-coupling and click chemistry reactions.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially for targeted therapies and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed to create sophisticated ligands for catalysis and molecular recognition applications.
• Bioconjugation and Probe Synthesis: The alkyne group is ideal for Huisgen cycloaddition (click chemistry) to attach fluorescent tags or other functional groups to biomolecules.
• Academic and Industrial R&D: A fundamental reagent for exploring new synthetic pathways and chemical transformations in organic chemistry.

Basic Information

Product Name	4-(3-Hydroxy-Prop-1-Ynyl)-Benzonitrile
CAS No.	80151-16-2
Molecular Formula	C10H7NO
Molecular Weight	157.17 g/mol
Synonyms	4-(3-Hydroxy-1-propynyl)benzonitrile; 4-(3-Hydroxyprop-1-yn-1-yl)benzonitrile; 4-(3-Hydroxypropynyl)benzonitrile; 4-Cyanophenyl propargyl alcohol; 1-(4-Cyanophenyl)-2-propyn-1-ol; 4-(2-Propyn-1-ol-1-yl)benzonitrile; p-Cyanophenyl propargyl alcohol
EINECS	Contact for details

Quality Control

Our 4-(3-Hydroxy-Prop-1-Ynyl)-Benzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its functional groups, the container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.