Description

1-Chloro-4-(2,2,2-Trifluoroethoxy)Benzene is a high-purity fluorinated aromatic ether building block, essential for advanced organic synthesis. This compound is valued for its unique combination of an electron-withdrawing trifluoroethoxy group and a reactive chloro substituent, enabling precise molecular modifications. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoroethoxy moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing properties like chemical resistance, low surface energy, and optical clarity.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl and heteroaryl structures.
• Organic Synthesis Building Block: Provides a platform for nucleophilic aromatic substitution and further functionalization in custom synthesis and medicinal chemistry projects.

Basic Information

Product Name	1-Chloro-4-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	80054-80-4
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	4-Chloro-1-(2,2,2-trifluoroethoxy)benzene; p-Chloro(2,2,2-trifluoroethoxy)benzene; 1-Chloro-4-(2,2,2-trifluoroethoxy)benzene; 4-(2,2,2-Trifluoroethoxy)chlorobenzene; Benzene, 1-chloro-4-(2,2,2-trifluoroethoxy)-; 2,2,2-Trifluoroethyl 4-chlorophenyl ether
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-(2,2,2-Trifluoroethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.