Description

1-Chloro-3-Fluoro-Propan-2-Ol: 1,3-Difluoropropan-2-Ol is a versatile fluorinated and chlorinated alcohol building block, valued for its bifunctional reactivity which enables the synthesis of complex molecules. This compound is essential for industries requiring high-purity intermediates to develop advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those containing fluorine for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom improves efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorine and reactive hydroxyl/chloro groups into polymer chains, altering surface properties and chemical resistance.
• Cross-coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed coupling reactions to form carbon-carbon bonds.
• Solvent & Additive for Specialty Formulations: Used in specialized formulations requiring a polar, fluorinated solvent component.

Basic Information

Product Name	1-Chloro-3-Fluoro-Propan-2-Ol: 1,3-Difluoropropan-2-Ol
CAS No.	8065-71-2
Molecular Formula	C3H5ClF2O
Molecular Weight	130.52 g/mol
Synonyms	1-Chloro-3-fluoropropan-2-ol; 1,3-Difluoropropan-2-ol; 2-Propanol, 1-chloro-3-fluoro-; 3-Fluoro-1-chloropropan-2-ol; 1-Chloro-3-fluoroisopropyl alcohol; 1,3-Difluoro-2-propanol; 2-Hydroxy-1-chloro-3-fluoropropane; Glycidyl chloride fluoride derivative
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-Fluoro-Propan-2-Ol is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing including GC, HPLC, and NMR to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of reactive functional groups, isolate from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Chloride Content	Confirmatory test
Density (20°C)	~1.3 g/mL
Refractive Index (n20D)	~1.42

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.