Description

Streptodornase/Streptokinase CAS NO 8048-16-6 is a sterile, lyophilized mixture of two purified bacterial enzymes, streptokinase and streptodornase, derived from specific strains of β-hemolytic streptococci. This enzymatic combination is critical for its potent fibrinolytic and proteolytic activities, which facilitate the breakdown of blood clots and necrotic tissue. It is an essential biopharmaceutical agent primarily required by manufacturers in the pharmaceutical and biotechnology sectors for the formulation of therapeutic products aimed at wound debridement and the treatment of specific thrombotic conditions.

Application

• Pharmaceutical Formulations: Key active ingredient in topical and injectable preparations for enzymatic debridement of necrotic tissue in wounds, ulcers, and burns.
• Thrombolytic Therapy: Used in research and development of treatments for acute myocardial infarction, pulmonary embolism, and deep vein thrombosis due to its clot-dissolving properties.
• Diagnostic Reagents: Component in in-vitro diagnostic kits for assessing fibrinolytic activity and related hematological parameters.
• Biochemical Research: Vital tool in life science research for studying the mechanisms of fibrinolysis, proteolysis, and cellular migration.
• Veterinary Medicine: Employed in veterinary pharmaceutical products for treating similar conditions in animals.
• Cell Culture & Tissue Engineering: Used in laboratory procedures to dissociate tissues or remove fibrin deposits from cell cultures.

Basic Information

Product Name	Streptodornase/Streptokinase
CAS No.	8048-16-6
Molecular Formula	Mixture of Proteins
Molecular Weight	Streptokinase: ~47 kDa; Streptodornase: ~30-35 kDa (Variable)
Synonyms	SK-SD; Varidase; Streptokinase-Streptodornase; Streptodornase and Streptokinase; Lumbrokinase (related); Staphylokinase (related); Plasminokinase; Fibrinolysin (Activated)
EINECS	Contact for details

Quality Control

Our Streptodornase/Streptokinase is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for potency, purity, and sterility. Quality control includes assays for enzymatic activity (SK and SD units), protein content, absence of residual moisture, and endotoxin levels. A comprehensive Certificate of Analysis (COA) documenting identity, purity, potency, and safety is provided with each shipment.

Storage

Preserve in the original sealed container at a controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. The product is hygroscopic (moisture-sensitive) and light-sensitive; it must be stored in a tightly closed container, protected from light and moisture. Avoid repeated temperature fluctuations. For long-term stability, store desiccated in a freezer (-20°C or below).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (IR/HPLC)	Conforms to reference standard
Potency (Streptokinase)	≥ XX,XXX IU/vial
Potency (Streptodornase)	≥ X,XXX units/vial
Protein Content (Biuret)	≥ 90%
Moisture (Karl Fischer)	≤ 3.0%
pH (Solution)	6.5 - 7.5
Sterility (Membrane Filtration)	Sterile
Bacterial Endotoxins (LAL)	< X.X EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.