Description

(2,3,4,5,6-Pentafluorophenyl)Acetyl Chloride is a highly reactive and versatile fluorinated building block essential for advanced organic synthesis. Its core value lies in introducing the pentafluorophenylacetyl moiety, a key structural motif that imparts unique electronic and steric properties to target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediates: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the pentafluorophenyl group enhances lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to tailor thermal stability and electronic properties.
• Peptide Modification & Bioconjugation: Useful for introducing fluorinated tags and labels into peptides, proteins, and other biomolecules for research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	(2,3,4,5,6-Pentafluorophenyl)Acetyl Chloride
CAS No.	832-72-4
Molecular Formula	C8H2ClF5O
Molecular Weight	244.55 g/mol
Synonyms	Pentafluorophenylacetyl Chloride; 2,3,4,5,6-Pentafluorophenylacetyl Chloride; 2-(Pentafluorophenyl)acetyl Chloride; α-Chloro-2,3,4,5,6-pentafluoroacetophenone; PFPAC; Pentafluorobenzeneacetyl Chloride; 2,3,4,5,6-Pentafluorobenzeneacetyl Chloride; (Perfluorophenyl)acetyl Chloride
EINECS	Contact for details

Quality Control

Our (2,3,4,5,6-Pentafluorophenyl)Acetyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments. We support compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.