Description

4,4,4-Trifluorobutylamine is a versatile fluorinated amine building block of significant interest in advanced chemical synthesis. Its value lies in the unique combination of a reactive primary amine group and a trifluoromethyl-terminated alkyl chain, which imparts desirable properties like enhanced lipophilicity and metabolic stability to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including protease inhibitors and kinase inhibitors, where the CF3 group can improve bioavailability and binding affinity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and stability.
• Polymer Modification: Employed to introduce fluorine into polymer backbones or side chains, yielding materials with altered surface properties, chemical resistance, and optical characteristics.
• Organic Synthesis Building Block: Utilized in various reactions, including reductive amination, peptide coupling, and as a precursor for heterocycles, facilitating the exploration of new chemical space.
• Surface Active Agents: Can be incorporated into the synthesis of fluorinated surfactants or coatings that require specific wetting and leveling properties.

Basic Information

Product Name	4,4,4-Trifluorobutylamine
CAS No.	819-46-5
Molecular Formula	C4H8F3N
Molecular Weight	127.11 g/mol
Synonyms	4,4,4-Trifluorobutylamine; 4,4,4-Trifluorobutan-1-amine; 1-Amino-4,4,4-trifluorobutane; 4,4,4-Trifluorobutylamine; Butylamine, 4,4,4-trifluoro-; 819-46-5; 4,4,4-Trifluor-1-butylamin; γ,γ,γ-Trifluorobutylamine
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorobutylamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistent quality and traceability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials. Due to its highly volatile and basic nature, it is recommended to store under an inert atmosphere (e.g., nitrogen) at temperatures between 2°C and 8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.