Description

Lithium Diethylamide is a highly reactive organolithium compound widely used as a strong, non-nucleophilic base in organic synthesis. Its value lies in its ability to efficiently deprotonate a broad range of substrates, including weakly acidic carbon-hydrogen bonds, enabling critical bond-forming reactions. This makes it an essential reagent for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where precise control over reaction pathways is paramount.

Application

• Pharmaceutical Intermediate Synthesis: As a key base for the generation of enolates and other carbanions in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Polymerization Catalyst/Initiator: Employed in anionic polymerization processes to produce specialized polymers with controlled molecular weights and architectures.
• Fine Chemical Manufacturing: Facilitating condensation, alkylation, and metallation reactions in the production of dyes, fragrances, and other high-value specialty chemicals.
• Agrochemical Synthesis: Used in the preparation of herbicides, pesticides, and plant growth regulators that require selective deprotonation steps.
• Lithiation Reactions: For the directed ortho-metalation (DoM) of aromatic compounds, introducing lithium atoms at specific positions for further functionalization.
• Research & Development: A fundamental tool in academic and industrial R&D labs for exploring new synthetic methodologies and constructing novel molecular frameworks.

Basic Information

Product Name	Lithium Diethylamide
CAS No.	816-43-3
Molecular Formula	C4H10LiN
Molecular Weight	79.06 g/mol
Synonyms	Lithium Diethylamide; Diethylamidolithium; N-Lithiodiethylamine; Lithium N,N-Diethylamide; LDA (common abbreviation); Diethylaminolithium; N,N-Diethylaminolithium; Lithium diethylamine
EINECS	Contact for details

Quality Control

Our Lithium Diethylamide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. We adhere to relevant industry standards for organometallic reagents. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive nature, this product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0% (as LiNEt2)
Concentration (Typical)	1.0 M in hexane/THF mixture
Free Amine	≤ 2.0%
Water (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.