Description

Tubulysin H is a highly potent cytotoxic peptide belonging to the tubulysin family of natural products, known for its exceptional ability to disrupt microtubule dynamics. This compound is of significant interest in advanced pharmaceutical research due to its mechanism of action, which involves the depolymerization of microtubules, leading to potent anti-mitotic and anti-angiogenic effects. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel anticancer therapeutics and antibody-drug conjugates (ADCs).

Application

• Anticancer Drug Discovery: Serves as a key payload or lead compound in the research and development of new chemotherapeutic agents targeting various solid tumors and hematological cancers.
• Antibody-Drug Conjugate (ADC) Payload: Used as the cytotoxic warhead in the synthesis of ADCs, where its high potency is leveraged for targeted cancer therapy.
• Mechanistic Biological Studies: Employed as a research tool to study microtubule biology, cell cycle arrest, and apoptosis in cellular and biochemical assays.
• Preclinical Evaluation: Utilized in in vitro and in vivo models to assess efficacy, pharmacokinetics, and toxicity profiles of potential drug candidates.
• Chemical Biology Probes: Acts as a scaffold for developing chemical probes to investigate specific biological pathways and target validation.

Basic Information

Product Name	Tubulysin H
CAS No.	799822-09-6
Molecular Formula	C45H67N5O10S
Molecular Weight	870.11 g/mol
Synonyms	Tubulysin H; Tubugis H; (2S,4R)-4-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-Hydroxy-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our Tubulysin H is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via techniques such as MS and NMR. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and strictly light-sensitive (protect from all light exposure). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.