Description

Hexacosanoyl Coenzyme A (Ammonium Salt) is a high-purity, long-chain fatty acyl-CoA ester derivative, essential for research in lipid metabolism and enzyme function studies. This compound serves as a critical biochemical tool for investigating the mechanisms of fatty acid elongation, β-oxidation, and other acyltransferase-mediated pathways. It is primarily utilized by researchers and scientists in pharmaceutical R&D, academic biochemistry, and metabolic disease research to elucidate complex biological processes and screen for potential therapeutic agents.

Application

• Biochemical Research: Used as a substrate for studying enzymes like elongases and acyl-CoA synthetases involved in very long-chain fatty acid (VLCFA) synthesis.
• Metabolic Pathway Analysis: Essential for in vitro assays to investigate the β-oxidation pathway of ultra-long-chain fatty acids in mitochondria and peroxisomes.
• Enzyme Kinetics & Inhibition Studies: Serves as a standard or substrate to determine kinetic parameters (Km, Vmax) and to screen for inhibitors of fatty acid metabolism enzymes.
• Lipidomics and Metabolomics: Employed as a reference standard for the identification and quantification of acyl-CoA species in complex biological samples using LC-MS/MS techniques.
• Cell Signaling Research: Investigated for its potential role in lipid-mediated signaling pathways and cellular regulation.
• Drug Discovery Platforms: Integrated into high-throughput screening assays targeting metabolic disorders such as adrenoleukodystrophy (ALD) or other VLCFA-related diseases.

Basic Information

Product Name	Hexacosanoyl Coenzyme A (Ammonium Salt)
CAS No.	799813-02-8
Molecular Formula	C47H86N7O17P3S • xNH3
Molecular Weight	~1180.2 (Free acid), Contact for exact salt form weight.
Synonyms	Cerotoyl-CoA; C26:0-CoA; Hexacosanoyl-CoA ammonium salt; Coenzyme A, S-hexacosanoate, ammonium salt; 26:0 CoA; Very Long-Chain Acyl-CoA (C26:0); Arachidyl-CoA (C26:0); CoASH(C26:0)
EINECS	Contact for details

Quality Control

Our Hexacosanoyl Coenzyme A (Ammonium Salt) is manufactured under controlled conditions to ensure high batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -70°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Enzymatic/UV)	≥ 90% (as Coenzyme A active form)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO (limited)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.