Description

(5Z,8Z,11Z,14Z-Eicosatetraenoyl) Coenzyme A (Ammonium Salt) is a high-purity, chemically defined derivative of arachidonic acid conjugated to coenzyme A. This specialized biochemical is a critical substrate for enzymatic studies, particularly in lipid metabolism and eicosanoid biosynthesis research. It is essential for researchers and manufacturers in pharmaceutical development, biochemical research, and diagnostic enzyme assay production who require precise and reliable tools for studying cyclooxygenase (COX) and lipoxygenase (LOX) pathways.

Application

• Enzymology Research: As a defined substrate for studying the kinetics and inhibition of enzymes like cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and various lipoxygenases (5-LOX, 12-LOX, 15-LOX).
• Drug Discovery & Screening: Used in high-throughput screening (HTS) assays to identify and characterize novel anti-inflammatory drug candidates targeting eicosanoid biosynthesis pathways.
• Biochemical Pathway Analysis: A key reagent for in vitro reconstitution of prostanoid and leukotriene synthesis pathways to investigate regulatory mechanisms and metabolic flux.
• Diagnostic Kit Manufacturing: Serves as a core component in the production of clinical diagnostic kits designed to measure specific enzyme activities in patient samples.
• Cell Signaling Studies: Utilized in cellular models to investigate the role of specific eicosanoid precursors in inflammatory and immunological responses.
• Reference Standard: Acts as a high-purity analytical standard for LC-MS or HPLC-based quantification of arachidonoyl-CoA and related metabolites in complex biological samples.

Basic Information

Product Name	(5Z,8Z,11Z,14Z-Eicosatetraenoyl) Coenzyme A (Ammonium Salt)
CAS No.	799812-93-4
Molecular Formula	C₄₁H₆₈N₇O₁₇P₃S
Molecular Weight	1048.0 g/mol (approximate)
Synonyms	Arachidonoyl-Coenzyme A, Ammonium Salt; Arachidonoyl-CoA; Arachidonic Acid Coenzyme A; 5Z,8Z,11Z,14Z-Eicosatetraenoyl-CoA; AA-CoA; all-cis-5,8,11,14-Eicosatetraenoyl-CoA; CoA(20:4(5Z,8Z,11Z,14Z))
EINECS	Contact for details

Quality Control

Every batch of (5Z,8Z,11Z,14Z-Eicosatetraenoyl) Coenzyme A (Ammonium Salt) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and stability. Our quality system is designed to meet the exacting requirements of research and pharmaceutical applications. Comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), identity confirmation (by MS, NMR), and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.