Description

1-(5-Fluoro-2-Hydroxyphenyl)-2-(Triphenylphosphoranylidene)Ethanone is a specialized organophosphorus compound, specifically a stabilized ylide, that serves as a critical synthetic intermediate. Its core value lies in enabling complex carbon-carbon and carbon-heteroatom bond-forming reactions under mild conditions, offering chemists a powerful tool for constructing advanced molecular scaffolds. This high-purity building block is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, especially those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides requiring specific fluorinated phenols.
• Wittig Reaction Reagent: Acts as a stabilized ylide for the stereoselective synthesis of alkenes and enones in complex molecule assembly.
• Ligand and Catalyst Development: Serves as a precursor for novel phosphine-based ligands used in transition metal catalysis.
• Material Science Research: Building block for creating organic electronic materials and specialty polymers with tailored properties.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new reaction pathways in organic synthesis.

Basic Information

Product Name	1-(5-Fluoro-2-Hydroxyphenyl)-2-(Triphenylphosphoranylidene)Ethanone
CAS No.	797054-15-0
Molecular Formula	C26H20FO2P
Molecular Weight	414.41 g/mol
Synonyms	(5-Fluoro-2-hydroxyphenyl)(triphenylphosphoranylidene)methyl ketone; 2-(Triphenylphosphoranylidene)-1-(5-fluoro-2-hydroxyphenyl)ethanone; 1-(5-Fluoro-2-hydroxyphenyl)-2-(triphenyl-λ5-phosphanylidene)ethan-1-one; Wittig Reagent Derivative (Fluorinated); 5-Fluoro-2-hydroxybenzoyl methylenetriphenylphosphorane; Stabilized Ylide 797054-15-0
EINECS	Contact for details

Quality Control

Our production of 1-(5-Fluoro-2-Hydroxyphenyl)-2-(Triphenylphosphoranylidene)Ethanone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and reactivity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.