Description

[3-Amino-5-(Trifluoromethyl)Phenyl]Boronic Acid is a high-value, multifunctional boronic acid derivative featuring both an amino group and a trifluoromethyl substituent on the aromatic ring. This unique structure makes it a critical building block in modern synthetic chemistry, particularly for cross-coupling reactions like the Suzuki-Miyaura reaction. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require precise molecular scaffolds to develop new active ingredients. The compound's trifluoromethyl group is prized for its ability to enhance metabolic stability and lipophilicity in target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the CF3 group improves weatherfastness and biological activity.
• Material Science Research: Serves as a monomer or linker in the development of organic electronic materials, metal-organic frameworks (MOFs), and advanced polymers.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a boronic acid coupling partner to form biaryl and heterobiaryl structures under palladium catalysis.
• Chemical Biology & Proteomics: Utilized in the design of chemical probes and affinity ligands for studying protein function and interactions.
• Liquid Crystal & OLED Development: Incorporated into the core structure of organic semiconductors and display materials to tune electronic properties.

Basic Information

Product Name	[3-Amino-5-(Trifluoromethyl)Phenyl]Boronic Acid
CAS No.	796857-60-8
Molecular Formula	C7H7BF3NO2
Molecular Weight	204.95 g/mol
Synonyms	(3-Amino-5-(trifluoromethyl)phenyl)boronic acid; 3-Amino-5-(trifluoromethyl)benzeneboronic acid; Boronic acid, B-[3-amino-5-(trifluoromethyl)phenyl]-; 5-(Trifluoromethyl)-3-aminophenylboronic acid; 3-Amino-α,α,α-trifluoro-m-tolueneboronic acid; 3-Amino-5-trifluoromethylphenylboronic acid; m-Amino-α,α,α-trifluorobenzeneboronic acid
EINECS	Contact for details

Quality Control

Our [3-Amino-5-(Trifluoromethyl)Phenyl]Boronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.