Description

n-Boc-5-Bromo-2-Chloro-D-Phenylalanine is a protected, non-natural amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial chiral building block for the development of complex bioactive molecules, particularly in pharmaceutical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing peptide-based drugs and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other peptide mimetics.
• Peptidomimetic Synthesis: Used to incorporate halogenated phenylalanine analogs into peptide chains to modulate biological activity, stability, and pharmacokinetic properties.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry: Serves as a valuable building block in solid-phase and solution-phase libraries for high-throughput screening and drug discovery.
• Agrochemical Research: Potential application in the synthesis of chiral compounds for crop protection agents.
• Academic Research: Employed in university and institutional labs for methodological development in asymmetric synthesis and organocatalysis.

Basic Information

Item	Detail
Product Name	n-Boc-5-Bromo-2-Chloro-D-Phenylalanine
CAS No.	794593-67-2
Molecular Formula	C₁₄H₁₇BrClNO₄
Molecular Weight	378.65 g/mol
Synonyms	(2R)-3-(5-Bromo-2-chlorophenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid; Boc-5-Br-2-Cl-D-Phe-OH; tert-Butyl (R)-3-(5-bromo-2-chlorophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (common misnomer for acid); D-5-Bromo-2-chlorophenylalanine N-Boc derivative; N-Boc-5-Bromo-2-chloro-D-Phenylalanine; Boc-D-5-Bromo-2-chloro-Phe-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(5-bromo-2-chlorophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-Boc-5-Bromo-2-Chloro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.