Description

Benzeneacetic Acid, 3,5-Difluoro-α-Hydroxy-, (αr)- is a high-purity chiral intermediate featuring a difluorinated aromatic ring and a hydroxy acid moiety. This compound is of significant commercial importance for the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals, where its specific stereochemistry and fluorine substitution are critical for biological activity. It is primarily utilized by research and development laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in the production of novel therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in therapeutic areas such as oncology, central nervous system (CNS) disorders, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for developing specialty polymers with unique optical or surface properties.
• Bioconjugation Chemistry: The carboxylic acid and hydroxyl groups provide handles for linking this molecule to peptides, proteins, or other biomolecules in probe development.
• Academic & Industrial R&D: Employed in chemical research for method development and exploring new synthetic pathways involving fluorinated compounds.

Basic Information

Product Name	Benzeneacetic Acid, 3,5-Difluoro-α-Hydroxy-, (αr)-
CAS No.	794566-88-4
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	(R)-2-Hydroxy-2-(3,5-difluorophenyl)acetic Acid; (αR)-α-Hydroxy-3,5-difluorobenzeneacetic Acid; (R)-3,5-Difluoromandelic Acid; (R)-2-(3,5-Difluorophenyl)-2-hydroxyacetic Acid; (R)-3,5-DFMA; (R)-Difluoromandelic Acid; (R)-α,3,5-Trifluorohydrocinnamic Acid derivative; Ar-Difluorohydroxyphenylacetic Acid
EINECS	Contact for details

Quality Control

Our Benzeneacetic Acid, 3,5-Difluoro-α-Hydroxy-, (αr)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.