Description

Vemakalant is a pharmaceutical compound with the CAS registry number 794466-70-9, recognized as a class III antiarrhythmic agent. It matters as a selective and rapid-acting atrial-selective potassium channel blocker developed for the acute cardioversion of recent-onset atrial fibrillation. This product is essential for pharmaceutical R&D departments, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the cardiovascular drug development sector.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in antiarrhythmic medications.
• Cardiovascular Research: Critical reference standard and intermediate in preclinical and clinical research for atrial fibrillation treatments.
• Drug Formulation Development: Used in the development of injectable formulations for the acute management of arrhythmias.
• Process Chemistry & Scale-up: Serves as a key intermediate or final product in chemical process development and optimization for GMP manufacturing.
• Analytical Method Development: Employed as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods.
• Regulatory Submissions: Supplied as a characterized compound for inclusion in regulatory filings (e.g., DMF, CMC sections) to health authorities like the FDA and EMA.

Basic Information

Product Name	Vemakalant
CAS No.	794466-70-9
Molecular Formula	C24H30N4O3
Molecular Weight	422.52 g/mol
Synonyms	RSD1235; (2R,3R)-N-[2-Hydroxy-3-[2-[(3R)-1-methyl-2-pyrrolidinyl]ethyl]phenyl]-4-morpholinecarboxamide; (2R,3R)-2-(2-Hydroxy-3-{2-[(3R)-1-methylpyrrolidin-2-yl]ethyl}phenyl)-N-(morpholin-4-yl)acetamide; Vemakalant hydrochloride; RSD 1235; Vemakalant (RSD1235); Atrial-selective potassium channel blocker
EINECS	Contact for details

Quality Control

Our Vemakalant is manufactured under strict quality systems to meet the exacting standards of pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and control of specified impurities and residual solvents. A Certificate of Analysis (COA) is provided with each shipment, detailing compliance with agreed specifications. We support regulatory requirements and can supply material suitable for use under GMP guidelines for non-clinical and clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere or in a controlled, dry environment. Recommended long-term storage at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.