Description

(Alphar,Alphar)-1,1'-Bis[α-(Dimethylamino)Benzyl]-(S,S)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]Ferrocene is a highly specialized, chiral ferrocenyl diphosphine ligand designed for asymmetric catalysis. This compound matters because it provides exceptional enantioselectivity and catalytic activity in critical carbon-carbon bond-forming reactions, enabling the synthesis of complex chiral molecules. It is primarily needed by pharmaceutical R&D departments and fine chemical manufacturers for the production of high-value active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including those for cardiovascular, CNS, and oncology treatments.
• Asymmetric C-C Bond Formation: Facilitates reactions such as asymmetric allylic alkylation and hydroformylation with high stereocontrol.
• Catalyst Screening & Development: Used in R&D for discovering and optimizing new catalytic processes for fine chemicals.
• Agrochemical Synthesis: Employed in the production of enantiomerically pure herbicides and pesticides.
• Academic & Industrial Research: A valuable tool for studying structure-activity relationships in homogeneous catalysis and developing novel synthetic methodologies.

Basic Information

Product Name	(Alphar,Alphar)-1,1'-Bis[α-(Dimethylamino)Benzyl]-(S,S)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]Ferrocene
CAS No.	793718-16-8
Molecular Formula	C66H72FeN2P2
Molecular Weight	1011.04 g/mol
Synonyms	(S,S)-Alphar-Ferrocene; (S,S)-Alphar-Fc; Josiphos SL-J009-1 type ligand; (S,S)-1,1'-Bis[α-(Dimethylamino)benzyl]-2,2'-bis(di-3,5-xylylphosphino)ferrocene; (S,S)-2,2'-Bis[Di(3,5-xylyl)phosphino]-1,1'-bis[α-(dimethylamino)benzyl]ferrocene; (S,S)-Alphar-Ferrocene Ligand; Chiral Josiphos Derivative; Asymmetric Ferrocenyl Diphosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous quality testing to ensure high purity, consistent enantiomeric excess (ee), and catalytic performance. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and chiral chromatography. Certificates of Analysis (COA) detailing purity, assay, and chiral purity are provided with each shipment. We adhere to strict internal standards suitable for pharmaceutical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This product is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light should be avoided to maintain catalytic activity and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.