Description

Bis(R-2-(4,5-Dihydro-3H-Binaphtho[1,2-C:2,1-E]-Phosphepino)Ethyl)Amine is a sophisticated chiral phosphine ligand, a key building block in advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are critical for the efficient and sustainable synthesis of single-enantiomer pharmaceuticals and fine chemicals. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Facilitates challenging C-C and C-X bond-forming reactions with high selectivity, useful for constructing complex molecular architectures.
• Asymmetric Allylic Substitution: Enables the creation of chiral centers via nucleophilic attack on allylic systems with excellent enantiomeric excess.
• Hydroformylation: Used as a chiral ligand in the asymmetric hydroformylation of alkenes to produce enantiomerically enriched aldehydes.
• Academic & Industrial R&D: A valuable tool for developing novel catalytic methodologies and exploring new reaction pathways in chemical research.
• Process Chemistry Optimization: Employed to improve the yield, selectivity, and sustainability of existing manufacturing routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Bis(R-2-(4,5-Dihydro-3H-Binaphtho[1,2-C:2,1-E]-Phosphepino)Ethyl)Amine
CAS No.	791630-00-7
Molecular Formula	C46H38NP2
Molecular Weight	681.73 g/mol
Synonyms	(R)-BINAPINE; (R)-2,2'-Bis(di(3,5-xylyl)phosphino)-1,1'-binaphthyl; (R)-2,2'-Bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; (R)-Xyl-BINAP; (R)-3,5-Xyl-BINAP; (R)-3,5-XylBINAP; (R)-XylBINAP; (R)-2,2'-Bis(di-3,5-xylylphosphino)-1,1'-binaphthyl
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure exceptional purity and performance consistency, critical for reproducible catalytic activity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.