Description

3-[[[(2R,4R)-4-Mercapto-2-Pyrrolidinyl]Carbonyl]Amino]Benzoic Acid is a high-purity, stereochemically defined chiral building block featuring a benzoic acid core linked to a protected thiol-containing pyrrolidine moiety. This compound is valued for its role as a key intermediate in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is essential for chemists and researchers in the life sciences sector who require precise, high-quality intermediates for constructing novel drug candidates, especially those targeting protease enzymes or requiring specific spatial orientation for activity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor programs.
• Protease Inhibitor Synthesis: Serves as a core structural component in the design and synthesis of potential inhibitors for various protease enzymes.
• Peptidomimetic Chemistry: Used in the construction of peptidomimetics, where its structure helps mimic peptide bonds and conformations for enhanced drug stability and bioavailability.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Bioconjugation & Probe Development: The free carboxylic acid and protected thiol groups offer handles for bioconjugation, useful in creating chemical probes for biochemical assays.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in asymmetric synthesis to induce stereoselectivity in complex molecular constructions.

Basic Information

Product Name	3-[[[(2R,4R)-4-Mercapto-2-Pyrrolidinyl]Carbonyl]Amino]Benzoic Acid
CAS No.	791582-43-9
Molecular Formula	C13H14N2O3S
Molecular Weight	278.33 g/mol
Synonyms	(2R,4R)-4-Mercapto-N-(3-carboxyphenyl)-2-pyrrolidinecarboxamide; 3-[[(2R,4R)-4-Mercaptopyrrolidine-2-carbonyl]amino]benzoic Acid; 3-[(2R,4R)-4-Mercapto-2-pyrrolidinecarboxamido]benzoic Acid; Benzoic acid, 3-[[[(2R,4R)-4-mercapto-2-pyrrolidinyl]carbonyl]amino]-; (R,R)-4-Mercapto-N-(3-carboxyphenyl)pyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our 3-[[[(2R,4R)-4-Mercapto-2-Pyrrolidinyl]Carbonyl]Amino]Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive. For long-term storage, consider storage under an inert gas such as argon or nitrogen in a sealed container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.