Description

1-Boc-4-(3-Bromophenoxy)Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine core with a brominated aromatic ether moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific molecular scaffolds into their target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and combinatorial chemistry to explore new chemical entities and optimize lead compounds.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective manipulation of the piperidine nitrogen in multi-step synthetic sequences.
• Cross-Coupling Reactions: The aryl bromide functionality enables participation in pivotal metal-catalyzed cross-coupling reactions, such as Suzuki, Negishi, or Buchwald-Hartwig amination.
• Agrochemical Research: Serves as a synthetic intermediate in the development of novel active ingredients for crop protection.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for fundamental research and custom synthesis projects.

Basic Information

Product Name	1-Boc-4-(3-Bromophenoxy)Piperidine
CAS No.	790667-54-8
Molecular Formula	C16H22BrNO3
Molecular Weight	356.26 g/mol
Synonyms	1-Boc-4-(3-bromophenoxy)piperidine; 1-(tert-Butoxycarbonyl)-4-(3-bromophenoxy)piperidine; tert-Butyl 4-(3-bromophenoxy)piperidine-1-carboxylate; 4-(3-Bromophenoxy)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(3-bromophenoxy)piperidine; Piperidine, 4-(3-bromophenoxy)-, 1-(1,1-dimethylethyl) ester; 790667-54-8
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(3-Bromophenoxy)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.