Description

D-Proline, 4-Hydroxy-, Methyl Ester, (4R)-Rel- (9Ci) CAS NO 790644-51-8 is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a high-value building block for the stereoselective construction of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications such as peptidomimetics, chiral catalysts, and the synthesis of bioactive natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Peptidomimetics & Drug Design: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in stereoselective transformations.
• Agrochemical Synthesis: Employed in the research and development of chiral herbicides, fungicides, and plant growth regulators.
• Biochemical Research: Utilized as a probe or standard in studies of enzyme mechanisms, protein structure, and metabolic pathways.
• Fine Chemical Building Block: Applied in the custom synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	D-Proline, 4-Hydroxy-, Methyl Ester, (4R)-Rel- (9Ci)
CAS No.	790644-51-8
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(4R)-4-Hydroxy-D-proline methyl ester; Methyl (4R)-4-hydroxy-D-prolinate; Methyl (4R)-4-hydroxypyrrolidine-2-carboxylate; D-4-Hydroxyproline methyl ester; (2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester; Rel-(4R)-4-Hydroxy-D-proline methyl ester; (R,R)-4-Hydroxyproline methyl ester
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Hydroxy-, Methyl Ester, (4R)-Rel- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.